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  • Clinical and molecular correlates of PD
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    nbsp 0183 32 Separately although aneuploidy has been shown to correlate with decreased responses to immunotherapy in melanoma and lung cancer it is not broadly associated with PD-L1 expression 29 32 33 Importantly we identified several molecular alterations that associated...

  • Pulmonary fibrosis associated with short and long sleep
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    nbsp 0183 32 The researchers then showed that pulmonary fibrosis is associated with short and long sleep duration using human data from the UK Biobank The link between sleep duration and lung fibrosis is...

  • Overexpressed immunoglobulin
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    nbsp 0183 32 In 2008 we firstly reported that ILT4 was enriched in tumor cells of non-small cell lung cancer NSCLC and predicted advanced tumor stages Subsequent studies by us and other groups showed that tumor cell-derived ILT4 directly regulated their proliferation invasion migration and epithelial-mesenchymal transition EMT and promoted tumor progression 12 13 14...

  • Human immunodeficiency virus
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    nbsp 0183 32 Vacuolar encephalomyelopathy a disregarded diagnosis lately was a major neurological disease in the terminal stages of human immunodeficiency virus HIV -1 infection in the pre-antiretroviral therapy ART era Granulomatous-lymphocytic interstitial lung disease GLILD was classically identified as a non-infectious complication of common variable immunodeficiency however it is now being...

  • Atezolizumab
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    nbsp 0183 32 Encephalitis associated with atezolizumab has rarely been reported as an immune-related adverse event A case of encephalitis caused by treatment with atezolizumab is presented A 56-year-old Japanese man with lung cancer previously treated with surgery...

  • Lung transplantation
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    nbsp 0183 32 Lung transplantation or pulmonary transplantation is a surgical procedure in which a patient s diseased lungs are partially or totally replaced by lungs which come from a donor Donor lungs can be retrieved from a living donor or a deceased donor A living donor can only donate one lung lobe With some lung diseases a recipient may only...

  • Inferring the role of the microbiome on survival in patients
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    nbsp 0183 32 Three recent studies have shown that microbes are associated with response and overall survival OS in renal cell carcinoma RCC non-small cell lung cancer NSCLC and melanoma 1 2 3 The microbiome may be a key player in response to ICI therapy and a...

  • Estimated dead space fraction and the ventilatory ratio are
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    nbsp 0183 32 Indirect indices for measuring impaired ventilation such as the estimated dead space fraction and the ventilatory ratio have been shown to be independently associated with an increased risk of mortality This study aimed to compare various methods for dead space estimation and the ventilatory ratio in patients with acute respiratory distress syndrome ARDS and to determine their independent...

  • Use of glucocorticoids in patients with acute respiratory
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    nbsp 0183 32 In our trial sequential analysis the required diversity-adjusted information size sample size = 2692 patients was not reached and the evidence was insufficient from the available RCTs Among patients with ARDS use of glucocorticoids is associated with a significant reduction in mortality and duration of mechanical ventilation without increased risk of hospital-acquired infections...

  • Association between vitamin D supplementation and
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    nbsp 0183 32 Results 50 trials with a total of 74 655 participants were identified Vitamin D supplementation was not associated with all cause mortality risk ratio 0 98 95 confidence interval 0 95 to 1 02 I 2 =0 cardiovascular mortality 0 98 0 88 to 1 08 0 or non-cancer non-cardiovascular mortality 1 05 0 93 to 1 18 0 Vitamin D supplementation statistically significantly reduced the...

  • Pulmonary cryptococcosis coexisting with central type lung
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    nbsp 0183 32 Pulmonary Cryptococcosis is a common fungal infection mainly caused by Cryptococcus neoformans/C gattii species in immunocompromised patients Cases of pulmonary cryptococcosis in patients with normal immune function are increasingly common in China Clinical and radiographic features of pulmonary cryptococcosis are various and without obvious characteristics so it is often...

  • Coal Workers Pneumoconiosis Black Lung Disease
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    nbsp 0183 32 Small mine size is associated with lung function abnormality and pneumoconiosis among underground coal miners in Kentucky ia and West ia Occup Environ Med 2014 Oct 71 10 690-4 Medline...

  • Functional roles of circular RNAs during epithelial
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    nbsp 0183 32 Wang L et al reported that circPTK2 inhibits non-small-cell lung carcinoma NSCLC metastasis by disrupting oncogenic miR-429 and miR-200b-3p and promoting transcriptional intermediary factor 1γ TIF1γ expression TIF1γ which is considered as a61 62...

  • lncRNA JPX/miR
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    nbsp 0183 32 MicroRNAs miRNAs and Twist1-induced epithelial-mesenchymal transition EMT in cancer cell dissemination are well established but the involvement of long noncoding RNAs lncRNAs in Twist1-mediated signaling remains largely unknown RT-qPCR and western blotting were conducted to detect the expression levels of lncRNA JPX and Twist1 in lung cancer cell lines and tissues The impact of...

  • Coal Workers Pneumoconiosis Black Lung Disease
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    nbsp 0183 32 Small mine size is associated with lung function abnormality and pneumoconiosis among underground coal miners in Kentucky ia and West ia Occup Environ Med 2014 Oct 71 10 690-4 Advanced pneumoconiosis among working underground...

  • Squamous cell carcinoma antigen
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    nbsp 0183 32 Squamous Cell Carcinoma Antigen SCCA-IgM is associated with interstitial lung disease ILD in systemic sclerosis SSc SCCA-IgM seems able to improve the diagnostic performance of total lung capacity TLC identifying patients with a very low risk of SSc-ILD...

  • Hypoxia preconditioning attenuates lung injury after
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    nbsp 0183 32 However this technique is associated with hypoxia and ischemia in the nondependent lung tissue 1 2 3 Moreover the nondependent lung is reventilated and reoxygenated when the surgical procedure is completed which triggers a well-characterized hypoxia-reoxygenation injury similar to ischemia-reperfusion injury 4...

  • Effects of inspiratory flow on lung stress pendelluft and
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    nbsp 0183 32 The degree of aeration and small-airway plugging by edema and secretions is extremely variable thus wide differences in local compliance and resistance can coexist within the lung 12 21 Lung units with different time constants i e compliance times resistance inflate at different rates long time constant units are slow while short time constant units are fast reacting...

  • Immune checkpoint inhibitors of PD
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    nbsp 0183 32 Since the discovery of immune checkpoint proteins there has been a special interest in developing antibodies that block programmed cell death 1 receptor PD-1 and programmed cell death receptor ligand 1 PD-L1 for a subset of cancer patients PD-1 signaling negatively regulates T cell-mediated immune responses and serves as a mechanism for tumors to evade an antigen-specific T...

  • DNA methylation is associated with lung function in never
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    nbsp 0183 32 Active smoking is the main risk factor for COPD Here epigenetic mechanisms may play a role since cigarette smoking is associated with differential DNA methylation in whole blood So far it is unclear whether epigenetics also play a role in subjects with COPD who never smoked Therefore we aimed to identify differential DNA methylation associated with lung function in never smokers We...

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